This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

Bisphosphonates are widely used in the treatment of diseases involving excessive bone
resorption, such as osteoporosis, cancer-associated bone disease, and Paget's disease of …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

Bisphosphonates (BPS) inhibit bone resorption and are divided into two classes according
to their chemical structure and mechanism of action: nonnitrogen containing BPS such as …

Bisphosphonates are currently the most important and effective class of anti-resorptive drugs
available, but the exact molecular mechanisms by which they inhibit osteoclast-mediated …

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …

In recent years, substantial progress has been made in understanding the mechanism for
bisphosphonate suppression of bone turnover. Bisphosphonates can now be distinguished …

Bisphosphonates (BPs) are widely used in the treatment of diseases associated with
excessive osteoclast-mediated bone resorption, such as osteoporosis. Although several …

▪ Abstract Bisphosphonates (BPs) are pyrophosphate analogs in which the oxygen bridge
has been replaced by carbon and diverse carbon side chains have generated a large family …