Peptides with dual antimicrobial–anticancer activity: Strategies to overcome peptide limitations and rational design of anticancer peptides

Y Liscano, J Oñate-Garzón, JP Delgado - Molecules, 2020 - mdpi.com
Peptides are naturally produced by all organisms and exhibit a wide range of physiological,
immunomodulatory, and wound healing functions. Furthermore, they can provide with …

Antimicrobial peptides with anticancer activity: Today status, trends and their computational design

M Kordi, Z Borzouyi, S Chitsaz, M hadi Asmaei… - Archives of Biochemistry …, 2023 - Elsevier
Some antimicrobial peptides have been shown to be able to inhibit the proliferation of
cancer cell lines. Various strategies for treating cancers with active peptides have been …

[HTML][HTML] Peptides with dual antimicrobial and anticancer activities

MR Felício, ON Silva, S Gonçalves, NC Santos… - Frontiers in …, 2017 - frontiersin.org
In recent years, the number of people suffering from cancer and multi-resistant infections has
increased, such that both diseases are already seen as current and future major causes of …

Antimicrobial/anticancer peptides: Bioactive molecules and therapeutic agents

K Kardani, A Bolhassani - Immunotherapy, 2021 - Future Medicine
Antimicrobial peptides (AMPs) have been known as host-defense peptides. These cationic
and amphipathic peptides are relatively short (∼ 5–50 L-amino acids) with molecular weight …

From antimicrobial to anticancer peptides: the transformation of peptides

Y Qin, ZD Qin, J Chen, CG Cai, L Li… - Recent patents on …, 2019 - ingentaconnect.com
Background: Antimicrobial peptides play an important role in the innate immune system.
Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat …

In Silico Models for Designing and Discovering Novel Anticancer Peptides

A Tyagi, P Kapoor, R Kumar, K Chaudhary, A Gautam… - Scientific reports, 2013 - nature.com
Use of therapeutic peptides in cancer therapy has been receiving considerable attention in
the recent years. Present study describes the development of computational models for …

Anti-cancer peptides: Their current trends in the development of peptide-based therapy and anti-tumor drugs

A Lath, AR Santal, N Kaur, P Kumari… - Biotechnology and …, 2023 - Taylor & Francis
Human cancer remains a cause of high mortality throughout the world. The conventional
methods and therapies currently employed for treatment are followed by moderate-to-severe …

Rational design of hybrid peptides: a novel drug design approach

C Wang, C Yang, Y Chen, L Ma, K Huang - Current medical science, 2019 - Springer
Peptides play crucial roles in various physiological and pathological processes.
Consequently, the investigation of peptide-based drugs is a highlight in the research and …

Peptide based antimicrobials: Design strategies and therapeutic potential

PK Hazam, R Goyal, V Ramakrishnan - Progress in Biophysics and …, 2019 - Elsevier
Therapeutic activity of antibiotics is noteworthy, as they are used in the treatment of microbial
infections. Regardless of their utility, there has been a steep decrease in the number of drug …

Synthetic molecular evolution of antimicrobial peptides

CH Chen, T Bepler, K Pepper, D Fu, TK Lu - Current opinion in …, 2022 - Elsevier
Highlights•Various peptide design methods have facilitated peptide–drug
development.•Only a few peptide therapeutics have entered the antibiotic market in the past …