Inflammation as the common biological link between depression and cardiovascular diseases: can carnosine exert a protective role?

G Caruso, CG Fresta, M Grasso… - Current Medicinal …, 2020 - ingentaconnect.com
Several epidemiological studies have clearly shown the high co-morbidity between
depression and Cardiovascular Diseases (CVD). Different studies have been conducted to …

[HTML][HTML] The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms

G Caruso, L Di Pietro, V Cardaci, S Maugeri… - Current Research in …, 2023 - Elsevier
Carnosine is a naturally occurring endogenous dipeptide composed by the ligation of β-
alanine and L-histidine performed particularly by tissues with an increased oxidative …

Carnosine decreases pma-induced oxidative stress and inflammation in murine macrophages

G Caruso, CG Fresta, A Fidilio, F O'Donnell, N Musso… - Antioxidants, 2019 - mdpi.com
Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This
naturally occurring molecule is present at high concentrations in several mammalian …

Effects of carnosine and histidine-containing dipeptides on biomarkers of inflammation and oxidative stress: a systematic review and meta-analysis

S Saadati, RH Kabthymer, G Aldini, A Mousa… - Nutrition …, 2023 - academic.oup.com
Context Carnosine and histidine-containing dipeptides (HCDs) are suggested to have anti-
inflammatory and antioxidative benefits, but their effects on circulating adipokines and …

Modulation of pro-oxidant and pro-inflammatory activities of m1 macrophages by the natural dipeptide carnosine

CG Fresta, A Fidilio, G Lazzarino, N Musso… - International journal of …, 2020 - mdpi.com
Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues,
existing at particularly high concentrations in the muscles and brain and possesses well …

Current therapeutic approaches for targeting inflammation in depression and cardiovascular disease

P Zuzarte, A Duong, ML Figueira… - Current drug …, 2018 - ingentaconnect.com
Background: Cardiovascular disease (CVD) and depression are extremely prevalent and
debilitating conditions. Evidence suggest that there is a two-way relationship between …

Understanding the antioxidant and carbonyl sequestering activity of carnosine: Direct and indirect mechanisms

G Aldini, B de Courten, L Regazzoni… - Free radical …, 2021 - Taylor & Francis
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …

[HTML][HTML] Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications

M Shao, X Lin, D Jiang, H Tian, Y Xu, L Wang, F Ji… - Psychiatry …, 2020 - Elsevier
Depression is a highly prevalent risk factor for both the onset of cardiovascular disease
(CVD) and the mortality of CVD patients, and people suffering from CVD are more likely to …

Cardiovascular disease and depression: A narrative review

X Li, J Zhou, M Wang, C Yang, G Sun - Frontiers in Cardiovascular …, 2023 - frontiersin.org
In clinical practice, it is frequently observed that cardiac and psychological disorders
frequently co-occur, leading to the emergence of a field known as cardiovascular disease …

Depression and cardiovascular disease: role of nitric oxide

VLM Pinto, T Brunini, MR Ferraz… - … Agents in Medicinal …, 2008 - ingentaconnect.com
Both depression and cardiovascular disease are major public health problems. Growing
evidence shows that depression is a risk factor for the development of coronary artery …