Streptomyces sp. GF3587 and 3546 were found to be imine-reducing strains with high R-
and S-selectivity by screening using 2-methyl-1-pyrroline (2-MPN). Their whole-cell catalysts …

Although the range of biocatalysts available for the synthesis of enantiomerically pure chiral
amines continues to expand, few existing methods provide access to secondary amines. To …

Imine reductases (IRED) are promising catalysts for the synthesis of optically pure
secondary cyclic amines. Three novel IREDs from Paenibacillus elgii B69, Streptomyces …

Biocatalytic imine reduction: A whole‐cell recombinant E. coli system, producing an (S)‐
selective imine reductase (IRED) from Streptomyces sp. GF3546, is developed. This …

Abstract A NADPH-dependent (S)-imine reductase (SIR) was purified to be homogeneous
from the cell-free extract of Streptomyces sp. GF3546. SIR appeared to be a homodimer …

Imine reductases are nicotinamide-dependent enzymes that catalyze the asymmetric
reduction of various imines to the corresponding amine products. Owing to the increasing …

Reducing reactions are among the most useful transformations for the generation of chiral
compounds in the fine‐chemical industry. Because of their exquisite selectivities, enzymatic …

Biocatalysis employing imine reductases is a promising approach for the one‐step
generation of chiral amines from ketones. The enzymes reported for this process suffer from …

Recent investigations on imine reductases (IREDs) have enriched the toolbox of potential
catalysts for accessing chiral amines, which are important building blocks for the …

Imine reductases (IREDs) have emerged as promising biocatalysts for the synthesis of chiral
amines. In this study, the asymmetric imine reductase‐catalyzed intermolecular reductive …