Sex differences exist in chronic pain pathologies, and gonadal estradiol (E2) alters the pain
sensation. The nocisensor transient receptor potential vanilloid 1 (TRPV1) receptor plays a …

There is mounting evidence that estrogens act directly on the nervous system to affect the
severity of pain. Estrogen receptors (ERs) are expressed by sensory neurons, and in …

Several trigeminal pain disorders show sex differences, and high levels of estrogens may
underlie these differences. The interaction between transient receptor potential vanilloid 1 …

Recent clinical studies have revealed sex differences in response to transient receptor
potential vanilloid 1 (TRPV1) agonist-induced pain. However, the mechanism of these …

In women, pain symptoms and nociceptive thresholds vary with the reproductive cycle,
suggesting the role of estrogen receptors (ERs) in modulating nociception. Our previous …

Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel
activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory …

Sex dependency in pain perception is well documented and is thought to be attributable to
the effect of reproductive hormones on nociceptive processing. In the present study, we …

Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation
channel responding to noxious heat, protons, and chemicals such as capsaicin. TRPV1 is …

Key points• TRPV1 (transient receptor potential vanilloid 1) channels are found throughout
the body in epithelial cells and in peripheral and central terminals in neurons. They exert a …

Objective To assess the functional changes of Transient receptor potential vanilloid 1
(TRPV1) receptor and to clarify its mechanism in a rat mono-iodoacetate (MIA)-induced joint …