ABSTRACT DNA methylation is an important regulator of gene expression and plays an
essential role in maintaining cellular function. Its role in carcinogenesis has been a topic of …

DNA methylation is an important epigenetic mechanism of transcriptional control. DNA
methylation plays an essential role in maintaining cellular function, and changes in …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

DNA methylation is an essential epigenetic mechanism involved in gene regulation.
Aberrant DNA methylation plays an important role in breast cancer initiation and progression …

Breast cancer is a heterogeneous and complex disease characterized by the combination of
multiple genetic alterations and is one of the leading causes of death among women. During …

DNA methylation and chromatin structure patterns are tightly linked components of the
epigenome, which regulate gene expression programming. Two contradictory changes in …

Traditionally, scientists have focused on structural changes in DNA sequences, such as
mutations and deletions, as the cause for altered patterns of gene expression in human …

Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of
dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation …

DNA methylation is a key epigenetic modifier involved in tumor formation, invasion, and
metastasis. The development of breast cancer is a complex process, and many studies have …

DNA Methylation Page 1 10 DNA Methylation Ian T. Johnson, Nigel J. Belshaw, and Giles O.
Elliott 10.1 Introduction Chromatin architecture is a major determinant of gene expression in …