A microstirring oral pill for improving the glucose-lowering effect of metformin

R Mundaca-Uribe, M Holay, A Abbas, N Askarinam… - ACS …, 2023 - ACS Publications
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia due to persistent insulin
resistance, resulting in elevated blood glucose levels. Metformin is the most prescribed oral …

A microstirring pill enhances bioavailability of orally administered drugs

R Mundaca‐Uribe, E Karshalev… - Advanced …, 2021 - Wiley Online Library
Majority of drugs are administered orally, yet their efficient absorption is often difficult to
achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill …

Glucose-responsive microparticle-loaded dissolving microneedles for selective delivery of metformin: a proof-of-concept study

N Syafika, SBA Azis, CK Enggi, HA Qonita… - Molecular …, 2023 - ACS Publications
Diabetes mellitus (DM) is a metabolic disorder that is one of the most common health
problems in the world, primarily type 2 DM (T2DM). Metformin (MTF), as the first-line …

Application of validated spectrophotometric method to quantify metformin in the development of glucose-responsive microparticles loaded dissolving microneedles

SB Abd Azis, N Syafika, HA Qonita, TRA Mahmud… - Microchemical …, 2022 - Elsevier
Metformin (MTF) is a first-line drug in the treatment of type 2 diabetes mellitus. Delivered
through the oral route, MTF has several limitations, mainly due to the side effects in …

Emerging nanoparticulate drug delivery systems of metformin

Y Chen, X Shan, C Luo, Z He - Journal of Pharmaceutical Investigation, 2020 - Springer
Background Driving the conventional drug in new applications has emerged as a research
hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of …

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

J Yu, Y Zhang, J Wang, D Wen, AR Kahkoska, JB Buse… - Nano Research, 2019 - Springer
Controlling postprandial glucose levels for diabetic patients is critical to achieve the tight
glycemic control that decreases the risk for developing long-term micro-and macrovascular …

Role of metformin in various pathologies: State-of-the-art microcapsules for improving its pharmacokinetics

A Gedawy, H Al-Salami, CR Dass - Therapeutic delivery, 2020 - Taylor & Francis
Metformin was originally derived from a botanical ancestry and became the most prescribed,
first-line therapy for Type 2 diabetes in most countries. In the last century, metformin was …

Autonomous untethered microinjectors for gastrointestinal delivery of insulin

A Ghosh, W Liu, L Li, GJ Pahapale, SY Choi, L Xu… - ACS …, 2022 - ACS Publications
The delivery of macromolecular drugs via the gastrointestinal (GI) tract is challenging as
these drugs display low stability as well as poor absorption across the intestinal epithelium …

Current perspective on the challenges in the development of metformin orally disintegrating tablets (ODTs)

MF bin Roslan, RT Widodo - Journal of Drug Delivery Science and …, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent
hyperglycaemia with significant morbidity and mortality rates. Currently, metformin is a drug …

Micromotor based mini-tablet for oral delivery of insulin

K Liu, Q Liu, J Yang, C Xie, S Wang, F Tong, J Gao… - ACS …, 2022 - ACS Publications
Diabetes is a metabolic disorder characterized by hyperglycemia due to defective insulin
secretion or its biological dysfunction. However, frequent subcutaneous injection of insulin …