A microstirring oral pill for improving the glucose-lowering effect of metformin
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia due to persistent insulin
resistance, resulting in elevated blood glucose levels. Metformin is the most prescribed oral …
resistance, resulting in elevated blood glucose levels. Metformin is the most prescribed oral …
A microstirring pill enhances bioavailability of orally administered drugs
R Mundaca‐Uribe, E Karshalev… - Advanced …, 2021 - Wiley Online Library
Majority of drugs are administered orally, yet their efficient absorption is often difficult to
achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill …
achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill …
Glucose-responsive microparticle-loaded dissolving microneedles for selective delivery of metformin: a proof-of-concept study
N Syafika, SBA Azis, CK Enggi, HA Qonita… - Molecular …, 2023 - ACS Publications
Diabetes mellitus (DM) is a metabolic disorder that is one of the most common health
problems in the world, primarily type 2 DM (T2DM). Metformin (MTF), as the first-line …
problems in the world, primarily type 2 DM (T2DM). Metformin (MTF), as the first-line …
Application of validated spectrophotometric method to quantify metformin in the development of glucose-responsive microparticles loaded dissolving microneedles
SB Abd Azis, N Syafika, HA Qonita, TRA Mahmud… - Microchemical …, 2022 - Elsevier
Metformin (MTF) is a first-line drug in the treatment of type 2 diabetes mellitus. Delivered
through the oral route, MTF has several limitations, mainly due to the side effects in …
through the oral route, MTF has several limitations, mainly due to the side effects in …
Emerging nanoparticulate drug delivery systems of metformin
Y Chen, X Shan, C Luo, Z He - Journal of Pharmaceutical Investigation, 2020 - Springer
Background Driving the conventional drug in new applications has emerged as a research
hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of …
hotspot for disease treatment. Metformin (MET) is conventionally used for the treatment of …
Glucose-responsive oral insulin delivery for postprandial glycemic regulation
Controlling postprandial glucose levels for diabetic patients is critical to achieve the tight
glycemic control that decreases the risk for developing long-term micro-and macrovascular …
glycemic control that decreases the risk for developing long-term micro-and macrovascular …
Role of metformin in various pathologies: State-of-the-art microcapsules for improving its pharmacokinetics
A Gedawy, H Al-Salami, CR Dass - Therapeutic delivery, 2020 - Taylor & Francis
Metformin was originally derived from a botanical ancestry and became the most prescribed,
first-line therapy for Type 2 diabetes in most countries. In the last century, metformin was …
first-line therapy for Type 2 diabetes in most countries. In the last century, metformin was …
Autonomous untethered microinjectors for gastrointestinal delivery of insulin
The delivery of macromolecular drugs via the gastrointestinal (GI) tract is challenging as
these drugs display low stability as well as poor absorption across the intestinal epithelium …
these drugs display low stability as well as poor absorption across the intestinal epithelium …
Current perspective on the challenges in the development of metformin orally disintegrating tablets (ODTs)
MF bin Roslan, RT Widodo - Journal of Drug Delivery Science and …, 2023 - Elsevier
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent
hyperglycaemia with significant morbidity and mortality rates. Currently, metformin is a drug …
hyperglycaemia with significant morbidity and mortality rates. Currently, metformin is a drug …
Micromotor based mini-tablet for oral delivery of insulin
K Liu, Q Liu, J Yang, C Xie, S Wang, F Tong, J Gao… - ACS …, 2022 - ACS Publications
Diabetes is a metabolic disorder characterized by hyperglycemia due to defective insulin
secretion or its biological dysfunction. However, frequent subcutaneous injection of insulin …
secretion or its biological dysfunction. However, frequent subcutaneous injection of insulin …