Chondrocytes are the main cell type in articular cartilage. They are embedded in an
avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

Osteoarthritis (OA) is the most common degenerative joint disease, and it is characterized by
articular cartilage loss. In part, OA is caused by aberrant anabolic and catabolic activities of …

Osteoarthritis (OA) is a joint disease that involves degeneration of articular cartilage, limited
intraarticular inflammation manifested by synovitis and changes in the subchondral bone …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

Musculoskeletal conditions are a major burden on individuals, healthcare systems, and
social care systems throughout the world, with indirect costs having a predominant …

Genetic studies and molecular cloning approaches have been successfully used to identify
several transcription factors that regulate the numerous stages of cartilage development …

Studies of chondrogenesis and embryonic limb development offer a wealth of knowledge
regarding signals that regulate the behavior of chondrocytes. Many such chondrogenic …

The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …

Cartilage serves multiple functions in the developing embryo and in postnatal life. Genetic
mutations affecting cartilage development are relatively common and lead to skeletal …