The role of vascular endothelial growth factor in angiogenesis

N Ferrara, HP Gerber - Acta haematologica, 2001 - karger.com
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an
angiogenic inducer as well as a mediator of vascular permeability. The biological effects of …

Role of vascular endothelial growth factor in regulation of physiological angiogenesis

N Ferrara - American Journal of Physiology-Cell …, 2001 - journals.physiology.org
Evidence accumulating over the last decade has established the fundamental role of
vascular endothelial growth factor (VEGF) as a key regulator of normal and abnormal …

VEGF: an update on biological and therapeutic aspects

N Ferrara - Current opinion in biotechnology, 2000 - Elsevier
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an
angiogenic inducer as well as a mediator of vascular permeability. VEGF is essential for …

Vascular endothelial growth factor: basic science and clinical progress

N Ferrara - Endocrine reviews, 2004 - academic.oup.com
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Angiogenesis—a new target for future therapy

NM Pandya, NS Dhalla, DD Santani - Vascular pharmacology, 2006 - Elsevier
Development of blood vessels from in situ differentiating endothelial cells (EC) is called
vasculogenesis, whereas sprouting of new blood vessels from the pre-existing ones is …

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications

N Ferrara - Seminars in oncology, 2002 - Elsevier
Angiogenesis, or formation of new blood vessels from pre-existing ones, is essential for
normal development and wound healing/reproductive functions in adults. Abnormal …

Vascular endothelial growth factor: much more than an angiogenesis factor

DR Senger - Molecular biology of the cell, 2010 - Am Soc Cell Biol
Vascular endothelial growth factor (VEGF) is best known as a cytokine essential for
embryonic vasculogenesis and for the angiogenesis associated with various pathologies …

Vascular endothelial growth factor

N Ferrara - Arteriosclerosis, thrombosis, and vascular biology, 2009 - Am Heart Assoc
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and
pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the …

Vascular endothelial growth factor and angiogenesis

ANN Hoeben, B Landuyt, MS Highley, H Wildiers… - Pharmacological …, 2004 - ASPET
Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Molecular and biological properties of vascular endothelial growth factor

N Ferrara - Journal of molecular medicine, 1999 - Springer
Vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and
abnormal angiogenesis. Recent evidence indicates that VEGF is essential for embryonic …