Systemic branched‐chain amino acid (BCAA) metabolism is dysregulated in
cardiometabolic diseases. We previously demonstrated that upregulated AMP deaminase 3 …

Parallel to major changes in fatty acid and glucose metabolism, defect in branched-chain
amino acid (BCAA) catabolism has also been recognized as a metabolic hallmark and …

The branched-chain amino acids (BCAA) accumulated in type 2 diabetes are independent
contributors to insulin resistance. The activity of branched-chain α-keto acid dehydrogenase …

Backgrounds Branched chain amino acid (BCAA) oxidation is impaired in cardiac insulin
resistance, leading to the accumulation of BCAAs and the first products of BCAA oxidation …

Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac
insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA …

Elevated levels of branched-chain amino acids (BCAAs) have recently been implicated in
the development of cardiovascular and metabolic diseases, but the molecular mechanisms …

Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or
hypertension, leading to heart failure and increased risk for death in diabetic patients. To …

Elevated blood branched-chain amino acids (BCAA) are often associated with insulin
resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or …

Elevated circulating branched‐chain amino acids (BCAAs) have been correlated with the
severity of insulin resistance, leading to recent investigations that stimulate BCAA …

Metabolic remodelling is an integral part of the pathogenesis of heart failure. Although much
progress has been made in our current understanding of the metabolic impairment involving …