[HTML][HTML] CircMap4k2 reactivated by aneurysm plication alleviates residual cardiac remodeling after SVR by enhancing cardiomyocyte proliferation in post-MI mice

J Yan, C Ai, Q Chen, Q Wang, Y Zhu, M Li… - Journal of Advanced …, 2023 - Elsevier
Introduction Surgical ventricular reconstruction (SVR) is an alternative therapeutic approach
in patients with refractory heart failure (HF), but residual remodeling after SVR limits the …

Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia–reperfusion injury

L Wang, J Feng, X Feng, D Meng, X Zhao… - Cardiovascular …, 2023 - academic.oup.com
Aims Regular exercise training benefits cardiovascular health and effectively reduces the
risk for cardiovascular disease. Circular RNAs (circRNAs) play important roles in cardiac …

Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p

JH Zeng, HJ Li, K Liu, CQ Liang, HY Wu… - DNA and Cell …, 2023 - liebertpub.com
Circular RNAs (circRNAs) are generally formed by the back-splicing of precursor mRNA.
Increasing evidence implicates the important role of circRNAs in cardiovascular diseases …

Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p

H Ni, W Li, Y Zhuge, S Xu, Y Wang, Y Chen… - International journal of …, 2019 - Elsevier
Abstract Background Circular RNAs (circRNAs) are emerging as powerful regulators of
cardiac development and disease. Nevertheless, detailed studies describing circRNA …

circRNA Hipk3 induces cardiac regeneration after myocardial infarction in mice by binding to Notch1 and miR-133a

X Si, H Zheng, G Wei, M Li, W Li, H Wang, H Guo… - … therapy-nucleic acids, 2020 - cell.com
The synergism between cardiomyogenesis and angiogenesis is essential for cardiac
regeneration. Circular RNAs (circRNAs) play pivotal roles in cell growth and angiogenesis …

Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis

X Fang, X Ao, D Xiao, Y Wang, Y Jia, P Wang… - Cellular & Molecular …, 2024 - Springer
Abstract Background Circular RNAs are enriched in cardiac tissue and play important roles
in the pathogenesis of heart diseases. In this study, we aimed to investigate the regulatory …

Loss of super-enhancer-regulated circRNA Nfix induces cardiac regeneration after myocardial infarction in adult mice

S Huang, X Li, H Zheng, X Si, B Li, G Wei, C Li… - Circulation, 2019 - Am Heart Assoc
Background: circRNAs (circular RNAs) are emerging as powerful regulators of cardiac
development and disease, but their roles in cardiac regeneration are still unknown. This …

CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway

D Ji, S Jin, Y Jiang, F Xu, S Fan, Y Zhao, X Liu… - Acta Pharmacologica …, 2024 - nature.com
Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for
adverse cardiac structural remodeling leading to heart failure and other critical conditions …

Oxidant stress-sensitive circRNA Mdc1 controls cardiomyocyte chromosome stability and cell cycle re-entry during heart regeneration

W Ma, X Wang, H Sun, B Xu, R Song, Y Tian… - Pharmacological …, 2022 - Elsevier
Targeting cardiomyocyte plasticity has emerged as a new strategy for promoting heart repair
after myocardial infarction. However, the precise mechanistic network underlying heart …

[PDF][PDF] Circular RNA IGF1R promotes cardiac repair via activating β-catenin signaling by interacting with DDX5 in mice post ischemic insults

TK Shan, TT Yang, P Jing, YL Bao, LH Zhou, T Zhu… - Research, 2024 - spj.science.org
The potential of circRNAs as biomarkers and therapeutic targets is becoming increasingly
evident, yet their roles in cardiac regeneration and myocardial renewal remain largely …