Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or
methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of …

Polyamine oxidase (PAO) and spermine oxidase (SMO) are involved in the catabolism of
polyamines–basic regulators of cell growth and proliferation. The discovery of selective …

Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in
μM-mM concentrations in all eukaryotic cells, is precisely regulated by coordinated activities …

The identification of increased polyamine concentrations in a variety of diseases from cancer
and psoriasis to parasitic infections has led to the hypothesis that manipulation of polyamine …

Spermine oxidase (SMO) is a recently described flavoenzyme belonging to the class of
polyamine oxidases (PAOs) and participating in the polyamine metabolism in animal cells …

N-alkylated polyamine analogues have potential as anticancer and antiparasitic drugs.
However, their metabolism in the host has remained incompletely defined thus potentially …

Abstract New polyamine derivatives 1–8, related to the previously reported N 1, N 12-
dibenzyldodecane-1, 12-diamine (Bis-Bza-Diado) and N 1-benzyl-spermine (BD6), have …

With the recent discovery of the polyamine catabolic enzyme spermine oxidase
(SMO/PAOh1), the apparent complexity of the polyamine metabolic pathway has increased …

Replacing protium with deuterium is an efficient method to modulate drug metabolism. N-
alkylated polyamine analogues are polyamine antimetabolites with proven anticancer …

The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present
in millimolar concentrations in all eukaryotic cells participating in the regulation of vital …