Mitochondrial dysfunction occurs in sensory neurons and may contribute to distal
axonopathy in animal models of diabetic neuropathy. The adenosine monophosphate …

Diabetic neuropathy is a neurological complication of diabetes that causes significant
morbidity and, because of the obesity-driven rise in incidence of type 2 diabetes, is …

Impaired adenosine monophosphate kinase (AMPK) signalling under hyperglycaemic
conditions is known to cause mitochondrial dysfunction in diabetic sensory neurons …

Objective Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of
diabetic patients leading to significant morbidity. There is impaired neurotrophic growth …

Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous
system where mitochondrial dysfunction has been implicated as an etiological factor …

Recent studies have demonstrated brain insulin signaling impairment and mitochondrial
dysfunction in diabetes. Hyperinsulinemia and hyperlipidemia arising from diabetes have …

Symmetrical sensory polyneuropathy, the most common form of diabetic neuropathy in
humans, is associated with a spectrum of structural changes in peripheral nerve that …

Diabetic neuropathy is a major complication of diabetes that results in the progressive
deterioration of the sensory nervous system. Mitochondrial dysfunction has been proposed …

Diabetes-induced damage to peripheral nerve culminates in development of peripheral
diabetic neuropathy (PDN), one of the most devastating complications of diabetes mellitus …

Survival of human peripheral nervous system neurons and associated distal axons is highly
dependent on energy. Diabetes invokes a maladaptation in glucose and lipid energy …