The development of drug resistance continues to be a dominant hindrance toward curative
cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …

Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

Multidrug resistance (MDR) remains one of the key determinants in chemotherapeutic
success of cancer patients. Often, acquired resistance is mediated by the overexpression of …

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein) and ABCG2 …

Simple Summary Overexpression of ABCB1 has been identified in a wide range of multidrug-
resistant cancers. ABCB1 can become upregulated in many ways, and understanding these …

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to
anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 …

Drug resistance is a severe limitation of chemotherapy of various malignancies. In particular
efflux transporters of the ATP-binding cassette family such as ABCB1 (P-glycoprotein), the …

Multidrug transporters constitute major mechanisms of MDR in human cancers. The ABCB1
(MDR1) gene encodes a well-characterized transmembrane transporter, termed P …

Drug resistance can occur at several levels and is the major cause of treatment failure in
oncology. The ABC (ATP-binding cassette) transporters, beginning with the discovery of P …