The importance of pyrimidines lies in the fact that they are structural components of a broad
spectrum of key molecules that participate in diverse cellular functions, such as synthesis of …

Pyrimidine nucleotides play a critical role in cellular metabolism serving as activated
precursors of RNA and DNA, CDP-diacylglycerol phosphoglyceride for the assembly of cell …

Genetic defects involving enzymes essential for pyrimidine nucleotide metabolism have
provided new insights into the vital physiological functions of these molecules in addition to …

The de novo biosynthesis of pyrimidine nucleotides provides essential precursors for
multiple growth-related events in higher eukaryotes. Assembled from ATP, bicarbonate and …

Highlights•Human pyrimidine nucleotide biosynthesis has been targeted for the treatment of
many diseases.•Chemotherapy combining DHODH and UCK inhibitors can be a broad …

Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Malaria is a major cause of morbidity and mortality in humans. Artemisinins remain as the
first-line treatment for Plasmodium falciparum (P. falciparum) malaria although drug …

By providing the necessary building blocks for nucleic acids and precursors for cell
membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and …

There are many disorders of pyrimidine metabolism and those that involve an alteration in
uridine metabolism have neurological and systemic effects, which provide insights into the …

The Immucillins are chemically stable analogues that mimic the ribocation and leaving-
group features of N-ribosyltransferase transition states. Infectious disease agents often rely …