The alveolar epithelial glycocalyx is a dense anionic layer of glycosaminoglycans (GAGs)
and proteoglycans that lines the apical surface of the alveolar epithelium. In contrast to the …

Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has
few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We …

The endothelial glycocalyx is a glycosaminoglycan-enriched endovascular layer that, with
the development of novel fixation and in vivo microscopy techniques, has been increasingly …

Background The most recent diagnostic criteria for sepsis include organ failure.
Microvascular endothelial injury is believed to lead to the multiple organ failure seen in …

Dysfunction of the microvasculature is a cardinal feature of sepsis pathophysiology, leading
to abnormal perfusion and tissue edema that can progress to significant injury in multiple …

The lung epithelial glycocalyx is a carbohydrate-enriched layer lining the pulmonary
epithelial surface. Although epithelial glycocalyx visualization has been reported, its …

The main pathophysiological mechanism of acute respiratory distress syndrome (ARDS)
invovles the increase in alveolar barrier permeability that is primarily caused by epithelial …

The endothelial glycocalyx is a heparan sulfate (HS)–rich endovascular structure critical to
endothelial function. Accordingly, endothelial glycocalyx degradation during sepsis …

Along with the recognition of a crucial role played by endothelial dysfunction secondarily
igniting cardiovascular, pulmonary, and renal complications, investigational focus has …

The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the
vascular lumen. It is enriched in proteoglycans, which are proteins attached to the …