Environmental reservoirs of antibiotic resistance (AR) are a growing concern that are
gathering more attention as potential sources for human infection. Carbapenem-resistant …

Carbapenems are the decision-making antimicrobials used to combat severe Gram-
negative bacterial infections in humans. Carbapenem resistance poses a potential public …

Carbapenemases, β-lactamases that inactivate carbapenems and most β-lactam antibiotics,
are most widely known for their ability to confer resistance to β-lactams. They include serine …

Carbapenems are used as last-resort drugs to treat infections caused by multidrug-resistant
bacteria. Despite the increasing number of reports of carbapenem-resistant …

Acquired carbapenemases pose one of the most pressing public health threats relating to
antibiotic resistance. In most countries, the number of carbapenemase-producing bacteria …

Evolution has provided environmental bacteria with a plethora of genes that give resistance
to antibiotic compounds. Under anthropogenic selection pressures, some of these genes are …

Infectious disease outbreaks have caused thousands of deaths and hospitalizations, along
with severe negative global economic impacts. Among these, infections caused by …

Carbapenemase-producing bacteria (CPB) are rare, multidrug resistant organisms most
commonly associated with hospitalized patients. Metropolitan wastewater treatment plants …

Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing
threat to global health. Both clonal spread and plasmid-mediated transmission contribute to …

The global emergence of carbapenemase-producing bacteria capable of hydrolyzing the
once effective carbapenem antibiotics is considered a contemporary public health concern …