Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants

X Zhang, W Xie, W Du, Y Liu, J Lin, W Yin… - Brain Imaging and …, 2023 - Springer
It has been well-established that high-altitude (HA) environments affect the human brain;
however, the differences in brain structural and functional networks between HA natives and …

Brain structural and functional alterations in native Tibetans living at high altitude

X Zhang, W Xie, Y Liu, M Li, J Lin, W Yin, L Yang, P Li… - Neuroscience, 2023 - Elsevier
Tibetans have adapted to high altitude environments. However, the genetic effects in their
brains have not been identified. Twenty-five native Tibetans living in Lhasa (3650 m) were …

Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude: a panel study

X Chen, Q Zhang, J Wang, J Liu, W Zhang… - Human Brain …, 2017 - Wiley Online Library
Background Cognitive and neuroimaging changes under chronic high‐altitude exposure
have never been followed up and dynamically assessed. Objectives To investigate the …

Adaptive modulation of adult brain gray and white matter to high altitude: structural MRI studies

J Zhang, H Zhang, J Li, J Chen, Q Han, J Lin, T Yang… - PloS one, 2013 - journals.plos.org
The aim of this study was to investigate brain structural alterations in adult immigrants who
adapted to high altitude (HA). Voxel-based morphometry analysis of gray matter (GM) …

The human brain in a high altitude natural environment: A review

X Zhang, J Zhang - Frontiers in Human Neuroscience, 2022 - frontiersin.org
With the advancement of in vivo magnetic resonance imaging (MRI) technique, more
detailed information about the human brain at high altitude (HA) has been revealed. The …

Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study

X Chen, H Li, Q Zhang, J Wang, W Zhang… - Human brain …, 2019 - Wiley Online Library
The study of individuals at high‐altitude (HA) exposure provides an important opportunity for
unraveling physiological and psychological mechanism of brain underlying hypoxia …

Reversible brain abnormalities in people without signs of mountain sickness during high-altitude exposure

C Fan, Y Zhao, Q Yu, W Yin, H Liu, J Lin, T Yang… - Scientific reports, 2016 - nature.com
A large proportion of lowlanders ascending to high-altitude (HA) show no signs of mountain
sickness. Whether their brains have indeed suffered from HA environment and the persistent …

Alteration in topological properties of brain functional network after 2‐year high altitude exposure: A panel study

Z Xin, X Chen, Q Zhang, J Wang, Y Xi, J Liu… - Brain and …, 2020 - Wiley Online Library
Introduction High altitude (HA) exposure leads to cognitive impairment while the underlying
mechanism is still unclear. Brain functional network is crucial for advanced functions, and its …

Long‐term acclimatization to high‐altitude hypoxia modifies interhemispheric functional and structural connectivity in the adult brain

J Chen, J Li, Q Han, J Lin, T Yang, Z Chen… - Brain and …, 2016 - Wiley Online Library
Background Structural and functional networks can be reorganized to adjust to
environmental pressures and physiologic changes in the adult brain, but such processes …

Cerebral and functional adaptation with chronic hypoxia exposure: a multi-modal MRI study

X Yan, J Zhang, J Shi, Q Gong, X Weng - Brain research, 2010 - Elsevier
The current study obtained multi-modal MRI data from 28 immigrant high altitude (HA) young
adults who were born and grew up at Qinghai-Tibetan plateau matched with 28 matched …