Immunotherapy has shown great promise in the fight against cancer, as evidenced by the
clinical efficacy of chimeric antigen receptor T cells in hematologic malignancies and …

The goal of achieving measurable response with cancer immunotherapy requires
counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that …

Anticancer agents continue to dominate the list of newly approved drugs, approximately half
of which are immunotherapies. This trend illustrates the considerable promise of cancer …

T lymphocytes function as major players in antigen-mediated cytotoxicity and have become
powerful tools for exploiting the immune system in tumor elimination. Several types of T cell …

The primary function of myeloid cells is to protect the host from infections. However, during
cancer progression or states of chronic inflammation, these cells develop into myeloid …

Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Myeloid-derived suppressor cells (MDSCs) are a population of immature myeloid cells
defined by their immunosuppression. Elevated levels of certain soluble cytokines in tumor …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that accumulate during pathologic conditions, such as cancer. Patients …

Immune evasion is a hallmark of cancer. While there are multiple different mechanisms that
cancer cells employ, myeloid-derived suppressor cells (MDSCs) are one of the key drivers of …

Chronic inflammation, typical of various diseases including cancer, is a “silent bomb within
the body,” leading to complications that are only evident in most cases upon their …