Main path and byways: non‐vesicular glutamate release by system xc− as an important modifier of glutamatergic neurotransmission
A Massie, S Boillee, S Hewett… - Journal of …, 2015 - Wiley Online Library
Abstract System xc− is a cystine/glutamate antiporter that exchanges extracellular cystine for
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …
Regulation of xCT expression and system function in neuronal cells
J Lewerenz, P Maher, A Methner - Amino acids, 2012 - Springer
The glutamate/cystine antiporter system x_ c^-transports cystine into cells in exchange for
glutamate at a ratio of 1: 1. It is composed of a specific light chain, xCT, and a heavy chain …
glutamate at a ratio of 1: 1. It is composed of a specific light chain, xCT, and a heavy chain …
Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc as a neuroprotective drug target
P Albrecht, J Lewerenz, S Dittmer… - CNS & Neurological …, 2010 - ingentaconnect.com
The glutamate/cystine antiporter system xc¯ transports cystine into cells in exchange for the
important neurotransmitter glutamate at a ratio of 1: 1. It is composed of a specific light chain …
important neurotransmitter glutamate at a ratio of 1: 1. It is composed of a specific light chain …
The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
J Lewerenz, SJ Hewett, Y Huang… - Antioxidants & redox …, 2013 - liebertpub.com
The antiporter system xc− imports the amino acid cystine, the oxidized form of cysteine, into
cells with a 1: 1 counter-transport of glutamate. It is composed of a light chain, xCT, and a …
cells with a 1: 1 counter-transport of glutamate. It is composed of a light chain, xCT, and a …
Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (system xc−) to normal and pathological glutamatergic …
R Bridges, V Lutgen, D Lobner, DA Baker - Pharmacological reviews, 2012 - ASPET
System xc− represents an intriguing target in attempts to understand the pathological states
of the central nervous system. Also called a cystine-glutamate antiporter, system xc …
of the central nervous system. Also called a cystine-glutamate antiporter, system xc …
The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
M Conrad, H Sato - Amino acids, 2012 - Springer
The oxidative stress-inducible cystine/glutamate exchange system, system xc−, transports
one molecule of cystine, the oxidized form of cysteine, into cells and thereby releases one …
one molecule of cystine, the oxidized form of cysteine, into cells and thereby releases one …
System xc‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
RJ Bridges, NR Natale, SA Patel - British journal of …, 2012 - Wiley Online Library
System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …
Increased expression of cystine/glutamate antiporter in multiple sclerosis
Background Glutamate excitotoxicity contributes to oligodendrocyte and tissue damage in
multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS …
multiple sclerosis (MS). Intriguingly, glutamate level in plasma and cerebrospinal fluid of MS …
The cystine‐glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain
S Ottestad‐Hansen, QX Hu, VV Follin‐Arbelet… - Glia, 2018 - Wiley Online Library
The cystine‐glutamate exchanger (xCT) promotes glutathione synthesis by catalyzing
cystine uptake and glutamate release. The released glutamate may modulate normal neural …
cystine uptake and glutamate release. The released glutamate may modulate normal neural …
Loss of system xc− does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure …
D De Bundel, A Schallier, E Loyens… - Journal of …, 2011 - Soc Neuroscience
System xc− exchanges intracellular glutamate for extracellular cystine, giving it a potential
role in intracellular glutathione synthesis and nonvesicular glutamate release. We report that …
role in intracellular glutathione synthesis and nonvesicular glutamate release. We report that …