Impact of smoking on inflammation: overview of molecular mechanisms

RB Gonçalves, RD Coletta, KG Silvério… - Inflammation …, 2011 - Springer
Background Inflammation is a critical component of normal tissue repair, as well as being
fundamental to the body's defense against infection. Environmental factors, such as …

Cigarette smoking and inflammation revisited

O Rom, K Avezov, D Aizenbud, AZ Reznick - Respiratory physiology & …, 2013 - Elsevier
Despite the significant health risks resulting from tobacco use, the prevalence of smokers
worldwide remains high. Cigarette smoking is one of the major sources of toxic chemical …

Nicotine inhibits the production of inflammatory mediators in U937 cells through modulation of nuclear factor-kB activation

N Sugano, K Shimada, K Ito, S Murai - Biochemical and biophysical …, 1998 - Elsevier
Cigarette smoke is a major risk factor for lung cancer and respiratory infections. This
increased susceptibility may result from cigarette smoke-induced impairment of the immune …

[HTML][HTML] Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?

F Qiu, CL Liang, H Liu, YQ Zeng, S Hou, S Huang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cigarette smoking is associated with numerous diseases and poses a serious challenge to
the current healthcare system worldwide. Smoking impacts both innate and adaptive …

Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: a review

Y Liu, L Lu, H Yang, X Wu, X Luo, J Shen, Z Xiao… - Environmental …, 2023 - Elsevier
Smoking is a serious global health issue. Cigarette smoking contains over 7000 different
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …

Cigarette smoke induces proinflammatory cytokine release by activation of NF-κB and posttranslational modifications of histone deacetylase in macrophages

SR Yang, AS Chida, MR Bauter… - … of Physiology-Lung …, 2006 - journals.physiology.org
Cigarette smoke-mediated oxidative stress induces an inflammatory response in the lungs
by stimulating the release of proinflammatory cytokines. Chromatin remodeling due to …

Immune-regulating effects of exercise on cigarette smoke-induced inflammation

A Madani, K Alack, MJ Richter… - Journal of inflammation …, 2018 - Taylor & Francis
Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction
and stroke and the central risk factor for the development of a bronchial carcinoma, smoking …

IKKα causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung

SR Yang, S Valvo, H Yao, A Kode… - American journal of …, 2008 - atsjournals.org
Cigarette smoke (CS) induces abnormal and sustained lung inflammation; however, the
molecular mechanism underlying sustained inflammation is not known. It is well known that …

Impact of tobacco‐smoke on key signaling pathways in the innate immune response in lung macrophages

MA Birrell, S Wong, MC Catley… - Journal of cellular …, 2008 - Wiley Online Library
Many of the healthcare consequences of cigarette smoking could be due to its ability to
compromise the immune system, and in respiratory diseases like chronic obstructive …

Nicotine in inflammatory diseases: anti-inflammatory and pro-inflammatory effects

W Zhang, H Lin, M Zou, Q Yuan, Z Huang… - Frontiers in …, 2022 - frontiersin.org
As an anti-inflammatory alkaloid, nicotine plays dual roles in treating diseases. Here we
reviewed the anti-inflammatory and pro-inflammatory effects of nicotine on inflammatory …