[HTML][HTML] Therapeutic perspectives for inflammation and senescence in osteoarthritis using mesenchymal stem cells, mesenchymal stem cell-derived extracellular …
MG Rizzo, TM Best, J Huard, M Philippon, F Hornicek… - Cells, 2023 - mdpi.com
Osteoarthritis (OA) is the most common cause of disability worldwide among the elderly.
Alarmingly, the incidence of OA in individuals less than 40 years of age is rising, likely due to …
Alarmingly, the incidence of OA in individuals less than 40 years of age is rising, likely due to …
Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis
Osteoarthritis (OA) is a common age-related disease that correlates with a high number of
senescent cells in joint tissues. Senescence has been reported to be one of the main drivers …
senescent cells in joint tissues. Senescence has been reported to be one of the main drivers …
[HTML][HTML] Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis
CJ Wu, RX Liu, SW Huan, W Tang, YK Zeng… - Arthritis research & …, 2022 - Springer
Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly
seen in the elderly that affects the whole “organ” including cartilage, subchondral bone …
seen in the elderly that affects the whole “organ” including cartilage, subchondral bone …
Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
PR Coryell, BO Diekman, RF Loeser - Nature Reviews Rheumatology, 2021 - nature.com
The development of osteoarthritis (OA) correlates with a rise in the number of senescent
cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been …
cells in joint tissues, and the senescence-associated secretory phenotype (SASP) has been …
Senolytic therapeutics: An emerging treatment modality for osteoarthritis
Osteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is
the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized …
the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized …
Targeting cellular senescence as a novel treatment for osteoarthritis
EM Astrike-Davis, P Coryell, RF Loeser - Current opinion in pharmacology, 2022 - Elsevier
Cellular senescence is associated with normal development and wound healing, but has
also been implicated in the pathogenesis of numerous aging-related diseases including …
also been implicated in the pathogenesis of numerous aging-related diseases including …
[HTML][HTML] Mesenchymal stem cell-derived exosomes and their therapeutic potential for osteoarthritis
Simple Summary Although mesenchymal stem cells (MSCs) have demonstrated their
therapeutic potential for osteoarthritis (OA) treatment in preclinical and clinical studies …
therapeutic potential for osteoarthritis (OA) treatment in preclinical and clinical studies …
[HTML][HTML] Mesenchymal stem cell therapy for osteoarthritis: the critical role of the cell secretome
P Mancuso, S Raman, A Glynn, F Barry… - … in bioengineering and …, 2019 - frontiersin.org
Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments.
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …
[HTML][HTML] Control of articular degeneration by extracellular vesicles from stem/stromal cells as a potential strategy for the treatment of osteoarthritis
MJ Alcaraz - Biochemical Pharmacology, 2024 - Elsevier
Osteoarthritis (OA) is a degenerative joint condition that contributes to years lived with
disability. Current therapeutic approaches are limited as there are no disease-modifying …
disability. Current therapeutic approaches are limited as there are no disease-modifying …
Extracellular vesicles from adipose‐derived mesenchymal stem cells downregulate senescence features in osteoarthritic osteoblasts
M Tofiño-Vian, MI Guillén… - Oxidative Medicine …, 2017 - Wiley Online Library
Osteoarthritis (OA) affects all articular tissues leading to pain and disability. The
dysregulation of bone metabolism may contribute to the progression of this condition …
dysregulation of bone metabolism may contribute to the progression of this condition …
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