Spermatogenesis is a complex process of proliferation and differentiation during male germ
cell development involving mitosis, meiosis and spermiogenesis. Endogenous and …

The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

This paper reviews the possible origin of sperm DNA fragmentation and focuses on the
nuclear events associated with spermiogenesis as a potential source of genetic instability …

Mammalian fertilization involves the direct in-teraction of the sperm and oocyte, fusion of the
cell membranes, and union of male and female gamete genomes. 1 The completion of this …

Reproductive diseases have become a growing worldwide problem and male factor plays
an important role in the reproductive diagnosis, prognosis and design of assisted …

Male reproductive health has received considerable attention in recent years. In addition to
declining sperm quality, fertility problems and increased incidence of testicular cancer, there …

Sperm DNA damage is considered a predictive factor for the clinical outcomes of patients
undergoing ART. Laboratory evidence suggests that zygotes and developing embryos have …

DNA damage in the male germline is associated with poor fertilization rates following IVF,
defective preimplantation embryonic development, and high rates of miscarriage and …

In mammals, there is a complex and intriguing relationship between DNA repair and
gametogenesis. DNA repair mechanisms are involved not only in the repair of different types …

Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …