The clinical pharmacogenetics implementation consortium: 10 years later

MV Relling, TE Klein, RS Gammal… - Clinical …, 2020 - Wiley Online Library
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www. cpicpgx.
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …

CPIC: clinical pharmacogenetics implementation consortium of the pharmacogenomics research network

MV Relling, TE Klein - Clinical Pharmacology & Therapeutics, 2011 - Wiley Online Library
The slow rate at which pharmacogenetic tests are being adopted in clinical practice is partly
due to the lack of specific guidelines on how to adjust medications on the basis of the …

[HTML][HTML] Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development …

KE Caudle, TE Klein, JM Hoffman, DJ Müller… - Current drug …, 2014 - ncbi.nlm.nih.gov
Abstract The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes
genotype-based drug guidelines to help clinicians understand how available genetic test …

The pharmacogenomics research network translational pharmacogenetics program: outcomes and metrics of pharmacogenetic implementations across diverse …

JA Luzum, RE Pakyz, AR Elsey… - Clinical …, 2017 - Wiley Online Library
Numerous pharmacogenetic clinical guidelines and recommendations have been
published, but barriers have hindered the clinical implementation of pharmacogenetics. The …

Evidence and resources to implement pharmacogenetic knowledge for precision medicine

KE Caudle, RS Gammal, M Whirl-Carrillo… - American Journal of …, 2016 - academic.oup.com
Purpose The current state of pharmacogenetic data curation and dissemination is described,
and evidence-based resources for applying pharmacogenetic data in clinical practice are …

Moving pharmacogenetics into practice: it's all about the evidence!

JA Luzum, N Petry, AK Taylor… - Clinical …, 2021 - Wiley Online Library
The evidence for pharmacogenetics has grown rapidly in recent decades. However, the
strength of evidence required for the clinical implementation of pharmacogenetics is highly …

The pharmacogenomics research network translational pharmacogenetics program: overcoming challenges of real‐world implementation

AR Shuldiner, MV Relling, JF Peterson… - Clinical …, 2013 - Wiley Online Library
The pace of discovery of potentially actionable pharmacogenetic variants has increased
dramatically in recent years. However, the implementation of this new knowledge for …

Challenges and opportunities in implementing pharmacogenetic testing in clinical settings

WC Chang, R Tanoshima, CJD Ross… - Annual Review of …, 2021 - annualreviews.org
The clinical implementation of pharmacogenetic biomarkers continues to grow as new
genetic variants associated with drug outcomes are discovered and validated. The number …

[HTML][HTML] PharmVar and the landscape of pharmacogenetic resources

A Gaedigk, M Whirl-Carrillo, VM Pratt… - Clinical …, 2020 - ncbi.nlm.nih.gov
Testing, reporting and translation of pharmacogenetics (PGx) into clinical recommendations
requires vast knowledge resources. The Pharmacogene Variation (PharmVar) Consortium …

Pharmacogenomics in practice: A review and implementation guide

D Kabbani, R Akika, A Wahid, AK Daly… - Frontiers in …, 2023 - frontiersin.org
Considerable efforts have been exerted to implement Pharmacogenomics (PGx), the study
of interindividual variations in DNA sequence related to drug response, into routine clinical …