Abstract Purpose Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-
resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly …

Purpose: A recent study reported that 5-fluorouracil (5-FU)-based chemotherapy is less
effective in treating patients with advanced colorectal cancer demonstrating …

Objectives: This study investigates the clinical significance of the gene encoding AP-2ε
(TFAP2E) in colorectal cancer (CRC) patients undergoing curative resection. Methods: A …

Chemotherapy is a mainstay of therapy for advanced gastric cancer (GC); however, owing to
drug resistances, the effectiveness of chemotherapy is not satisfactory for some patients with …

Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently
observed in colorectal cancer (CRC). The association between APC promoter methylation …

Background Chemotherapy for advanced colorectal cancer leads to improved survival;
however, predictors of response to systemic treatment are not available. Genomic and …

Objective. To investigate methylation of the adenomatosis polyposis coli homologue (APC2)
promoter and its correlation with prognostic implications in Chinese colorectal cancer …

Background: Gene promoter methylation is a mechanism for tumor suppressor gene
silencing and inactivation. The development of highly sensitive methods for revealing …

Hypoxic conditions during the formation of colorectal cancer may support the development
of more aggressive tumors. Hypoxia-inducible factor (HIF) is a heterodimeric complex …

Previous studies investigating the association between adenomatous polyposis coli (APC)
gene promoter methylation and colorectal cancer (CRC) have yielded conflicting results …