Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by
reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells …

Simple Summary Reactive oxygen species (ROS) are unstable derivatives of oxygen that
are generated naturally as products or biproducts of biological reactions. ROS, such as …

Abstract Members of the Peroxiredoxin (Prx) family are major cellular antioxidants that
scavenge hydrogen peroxide and play essential roles in oxidative stress and cell signaling …

Abstract Peroxiredoxin I (Prx I), an antioxidant enzyme, has multiple functions in human
cancer. However, the role of Prx I in hepatic tumorigenesis has not been characterized. Here …

Abstract Peroxiredoxin 1 (Prx1) has been found to be elevated in several human cancers.
The cell survival–enhancing function of Prx1 is traditionally attributed to its reactive oxygen …

Cancer stem cells (CSCs) represent a sub-population of cancer cells with the ability to
regulate stemness-associated properties which are specifically responsible for unlimited …

Purpose The mammalian peroxiredoxin (PRX) family contains six members that provide
antioxidant defense in different cell types by removing reactive oxygen species (ROS) …

Cigarette smoke, the major risk factor for lung cancer, induces an accumulation of reactive
oxygen species. These have multiple effects on cell defense, cell proliferation and cell …

Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …

In the past decade, a new family of highly conserved antioxidant enzymes, Peroxiredoxins
(Prxs), have been discovered and defined. There are two major Prx subfamilies: one …