SIRT7 promotes thyroid tumorigenesis through phosphorylation and activation of Akt and p70S6K1 via DBC1/SIRT1 axis

H Li, Z Tian, Y Qu, Q Yang, H Guan, B Shi, M Ji, P Hou - Oncogene, 2019 - nature.com
SIRT7 is an NAD+-dependent histone/non-histone deacetylase, which is highly expressed
in different types of cancer including thyroid cancer; however, its biological function in …

[HTML][HTML] SIRT6 is upregulated and associated with cancer aggressiveness in papillary thyroid cancer via BRAF/ERK/Mcl‑1 pathway

N Qu, JQ Hu, L Liu, TT Zhang… - International …, 2017 - spandidos-publications.com
Abstract Sirtuin 6 (SIRT6) is a member of the SIRT family NAD+‑dependent deacetylases
reported to function in controlling organism homeostasis, lifespan, and diseases. This study …

SIRT4 inhibits the proliferation, migration, and invasion abilities of thyroid cancer cells by inhibiting glutamine metabolism

Z Chen, J Lin, S Feng, X Chen, H Huang… - OncoTargets and …, 2019 - Taylor & Francis
Background SIRT4, a protein localized in the mitochondria, is one of the least characteristic
members of the sirtuin family. It is known that SIRT4 has deacetylase activity and plays a role …

The Role of Sirtuin 6 in the Deacetylation of Histone Proteins as a Factor in the Progression of Neoplastic Disease

M Baran, P Miziak, A Stepulak, M Cybulski - International Journal of …, 2023 - mdpi.com
SIRT6 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase,
predominantly located in the nucleus, that is involved in the processes of histone …

Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma

C Geng, C Zhang, J Zhang, P Gao… - Journal of cellular …, 2018 - Wiley Online Library
Sirt family has been reported playing a significant role in the cancer development, especial
its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating …

A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity

J Cai, Y Zuo, T Wang, Y Cao, R Cai, FL Chen, J Cheng… - Oncogene, 2016 - nature.com
Sirt6 is a histone deacetylase with NAD+-dependent activity. Sirt6 has been shown as a
tumor suppressor partially via inhibiting the expression of c-Myc target genes and ribosome …

Oncogenic SIRT7 inhibits GATA4 transcriptional activity and activates the Wnt signaling pathway in ovarian cancer

G Li, W Xu, X Li, M Chen, Y Shi, M Wei, D Peng - Gynecologic Oncology, 2023 - Elsevier
Abstract Objective Sirtuin-7 (SIRT7) is a class III histone deacetylase that plays an important
role in cancer development and frequently overexpressed in carcinomas. In this study, the …

[HTML][HTML] Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway

P Mu, KUN Liu, Q Lin, W Yang, DAN Liu… - Oncology …, 2019 - spandidos-publications.com
Abstract Sirtuin7 (Sirt7) is a member of the Sir2 histone deacetylase family that functions in a
number of physiological processes, including cellular metabolism, ageing and apoptosis …

[PDF][PDF] The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.

J Zhang, XJ Yin, CJ Xu, YX Ning… - European Review for …, 2015 - europeanreview.org
Art. 1.1475/ringraziamenti Page 1 European Review for Medical and Pharmacological
Sciences 818 Abstract. – OBJECTIVE: SIRT6 belongs to the NAD+-dependent class III …

[HTML][HTML] SIRT 1 overexpression is associated with metastasis of pancreatic ductal adenocarcinoma (PDAC) and promotes migration and growth of PDAC cells

S Li, H Hong, H Lv, G Wu, Z Wang - Medical Science Monitor …, 2016 - ncbi.nlm.nih.gov
SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma
(PDAC) and Promotes Migration and Growth of PDAC Cells - PMC Back to Top Skip to main …