Pupil diameter is not an accurate real-time readout of locus coeruleus activity

M Megemont, J McBurney-Lin, H Yang - Elife, 2022 - elifesciences.org
Pupil diameter is often treated as a noninvasive readout of activity in the locus coeruleus
(LC). However, how accurately it can be used to index LC activity is not known. To address …

[PDF][PDF] More than meets the eye: the relationship between pupil size and locus coeruleus activity

VD Costa, PH Rudebeck - Neuron, 2016 - cell.com
More than Meets the Eye: the Relationship between Pupil Size and Locus Coeruleus Activity Page
1 More than Meets the Eye: the Relationship between Pupil Size and Locus Coeruleus Activity …

Pupil diameter covaries with BOLD activity in human locus coeruleus

PR Murphy, RG O'connell, M O'sullivan… - Human brain …, 2014 - Wiley Online Library
The locus coeruleus‐noradrenergic (LC–NA) neuromodulatory system has been implicated
in a broad array of cognitive processes, yet scope for investigating this system's function in …

[HTML][HTML] Pupil diameter tracks lapses of attention

RL Van Den Brink, PR Murphy, S Nieuwenhuis - PloS one, 2016 - journals.plos.org
Our ability to sustain attention for prolonged periods of time is limited. Studies on the
relationship between lapses of attention and psychophysiological markers of attentional …

[PDF][PDF] Dynamic lateralization of pupil dilation evoked by locus coeruleus activation results from sympathetic, not parasympathetic, contributions

Y Liu, C Rodenkirch, N Moskowitz, B Schriver, Q Wang - Cell reports, 2017 - cell.com
Pupil size is collectively controlled by the sympathetic dilator and parasympathetic sphincter
muscles. Locus coeruleus (LC) activation has been shown to evoke pupil dilation, but how …

A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents

M Privitera, KD Ferrari, LM von Ziegler, O Sturman… - Nature protocols, 2020 - nature.com
The locus coeruleus (LC) is a region in the brainstem that produces noradrenaline and is
involved in both normal and pathological brain function. Pupillometry, the measurement of …

[PDF][PDF] Relationships between pupil diameter and neuronal activity in the locus coeruleus, colliculi, and cingulate cortex

S Joshi, Y Li, RM Kalwani, JI Gold - Neuron, 2016 - cell.com
Changes in pupil diameter that reflect effort and other cognitive factors are often interpreted
in terms of the activity of norepinephrine-containing neurons in the brainstem nucleus locus …

[HTML][HTML] Your eyes give you away: prestimulus changes in pupil diameter correlate with poststimulus task-related EEG dynamics

L Hong, JM Walz, P Sajda - PloS one, 2014 - journals.plos.org
Pupillary measures have been linked to arousal and attention as well as activity in the
brainstem's locus coeruleus norepinephrine (LC-NE) system. Similarly, there is evidence …

[HTML][HTML] From pupil to the brain: New insights for studying cortical plasticity through pupillometry

A Viglione, R Mazziotti, T Pizzorusso - Frontiers in neural circuits, 2023 - frontiersin.org
Pupil size variations have been associated with changes in brain activity patterns related
with specific cognitive factors, such as arousal, attention, and mental effort. The locus …

[HTML][HTML] Brain networks underlying eye's pupil dynamics

M DiNuzzo, D Mascali, M Moraschi, G Bussu… - Frontiers in …, 2019 - frontiersin.org
Phasic changes in eye's pupil diameter have been repeatedly observed during cognitive,
emotional and behavioral activity in mammals. Although pupil diameter is known to be …