Chemical–genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy
Current chemotherapy against Mycobacterium tuberculosis (Mtb), an important human
pathogen, requires a multidrug regimen lasting several months. While efforts have been …
pathogen, requires a multidrug regimen lasting several months. While efforts have been …
Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance
AN Samuels, ER Wang, GA Harrison… - Frontiers in cellular …, 2022 - frontiersin.org
Treatment of Mycobacterium tuberculosis (Mtb) infections is particularly arduous. One
challenge to effectively treating tuberculosis is that drug efficacy in vivo often fails to match …
challenge to effectively treating tuberculosis is that drug efficacy in vivo often fails to match …
Central carbon metabolism remodeling as a mechanism to develop drug tolerance and drug resistance in Mycobacterium tuberculosis
Suboptimal efficacy of the current antibiotic regimens and frequent emergence of antibiotic-
resistant Mycobacterium tuberculosis (Mtb), an etiological agent of tuberculosis (TB), render …
resistant Mycobacterium tuberculosis (Mtb), an etiological agent of tuberculosis (TB), render …
The role of fatty acid metabolism in drug tolerance of Mycobacterium tuberculosis
Mycobacterium tuberculosis can cocatabolize a range of carbon sources. Fatty acids are
among the carbons available inside the host's macrophages. Here, we investigated the …
among the carbons available inside the host's macrophages. Here, we investigated the …
Harnessing biological insight to accelerate tuberculosis drug discovery
Conspectus Tuberculosis (TB) is the leading cause of mortality globally resulting from an
infectious disease, killing almost 1.6 million people annually and accounting for …
infectious disease, killing almost 1.6 million people annually and accounting for …
Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs
RC Lavin, C Johnson, YM Ahn, KM Kremiller… - PLoS …, 2021 - journals.plos.org
Sensing and response to environmental cues, such as pH and chloride (Cl−), is critical in
enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent …
enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent …
Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis
Human tuberculosis is caused by members of the Mycobacterium tuberculosis complex
(MTBC) that vary in virulence and transmissibility. While genome-wide association studies …
(MTBC) that vary in virulence and transmissibility. While genome-wide association studies …
Modeling the Metabolic State of Mycobacterium tuberculosis Upon Infection
RA Rienksma, PJ Schaap… - Frontiers in cellular …, 2018 - frontiersin.org
Genome-scale metabolic models of Mycobacterium tuberculosis (Mtb), the causative agent
of tuberculosis, have been envisioned as a platform for drug discovery. By systematically …
of tuberculosis, have been envisioned as a platform for drug discovery. By systematically …
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
H Kim, SJ Shin - Cellular and Molecular Life Sciences, 2023 - Springer
Lipid species play a critical role in the growth and virulence expression of Mycobacterium
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …
tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy …
Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis
The co‐catabolism of multiple host‐derived carbon substrates is required by Mycobacterium
tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, the metabolic …
tuberculosis (Mtb) to successfully sustain a tuberculosis infection. However, the metabolic …