Abstract The Transforming Growth Factor-β (TGFβ) signaling pathway controls transcription
by regulating enhancer activity. How TGFβ-regulated enhancers are selected and what …

Vertebrate genomes are partitioned into chromatin domains or topologically associating
domains (TADs), which are typically bound by head-to-head pairs of CTCF binding sites …

Estrogen receptor α (ERα) is an enhancer activating transcription factor, a key driver of
breast cancer and a main target for cancer therapy. ERα-mediated gene regulation requires …

During organism development, a diversity of cell types emerges with disparate, yet stable
profiles of gene expression with distinctive cellular functions. In addition to gene promoters …

During neurogenesis, dynamic developmental cues, transcription factors and histone
modifying enzymes regulate the gene expression programs by modulating the activity of …

Millions of putative transcriptional regulatory elements (TREs) have been cataloged in the
human genome, yet their functional relevance in specific pathophysiological settings …

It is now well accepted that cell-type specific gene regulation is under the purview of
enhancers. Great strides have been made recently to characterize and identify enhancers …

Enhancers are cis-regulatory sequences located distally to target genes. These sequences
consolidate developmental and environmental cues to coordinate gene expression in a …

Here, we present Perturb-ATAC, a method that combines multiplexed CRISPR interference
or knockout with genome-wide chromatin accessibility profiling in single cells based on the …

Enhancers serve as critical regulatory elements in higher eukaryotic cells. The
characterization of enhancer function has evolved primarily from genome‐wide …