[HTML][HTML] Amino-pyrazoles in medicinal chemistry: A review

M Lusardi, A Spallarossa, C Brullo - International journal of molecular …, 2023 - mdpi.com
A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential.
Consequently, the search for new pyrazole-based compounds is of great interest to the …

5-Amino-pyrazoles: potent reagents in organic and medicinal synthesis

A Shaabani, MT Nazeri, R Afshari - Molecular diversity, 2019 - Springer
Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the
construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents …

Recently reported biological activities of pyrazole compounds

JV Faria, PF Vegi, AGC Miguita, MS Dos Santos… - Bioorganic & medicinal …, 2017 - Elsevier
The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms.
Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved …

The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review.

J Dwivedi, S Sharma, S Jain, A Singh - Mini Reviews in Medicinal …, 2018 - europepmc.org
Pyrazole nucleus is a unique structural scaffold which acts as an interesting template for
combinatorial as well as medicinal chemistry. This review presents a detailed overview on …

Recent advances in bioactive pyrazoles

ŞG Küçükgüzel, S Şenkardeş - European Journal of Medicinal Chemistry, 2015 - Elsevier
Pyrazole is a five membered and two-nitrogen containing heterocyclic ring. These structures
have been investigated in the development of novel compounds with hypoglycemic …

Biologically active pyrazole derivatives

A Ansari, A Ali, M Asif - New Journal of Chemistry, 2017 - pubs.rsc.org
Nitrogen-containing heterocyclic compounds and their derivatives have historically been
invaluable as a source of therapeutic agents. Pyrazole, which has two nitrogen atoms and …

[HTML][HTML] Synthesis and pharmacological activities of pyrazole derivatives: A review

K Karrouchi, S Radi, Y Ramli, J Taoufik, YN Mabkhot… - Molecules, 2018 - mdpi.com
Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

[HTML][HTML] Evaluation of substituted pyrazole-based kinase inhibitors in one decade (2011–2020): Current status and future prospects

MI El-Gamal, SO Zaraei, MM Madkour, HS Anbar - Molecules, 2022 - mdpi.com
Pyrazole has been recognized as a pharmacologically important privileged scaffold whose
derivatives produce almost all types of pharmacological activities and have attracted much …

4,5-Dihydro-1H-pyrazole: an indispensable scaffold

JM Alex, R Kumar - Journal of enzyme inhibition and medicinal …, 2014 - Taylor & Francis
Pyrazoles, categorized as nitrogen-containing heterocycles, are well known for their
interminable participation in the field of perpetual research and development of …

Pyrazole containing natural products: Synthetic preview and biological significance

V Kumar, K Kaur, GK Gupta, AK Sharma - European Journal of Medicinal …, 2013 - Elsevier
A large number of structurally diverse natural compounds containing azole nucleus
constitute an important class of biologically active heterocycles that are gaining more …