Adaptation to the nutritional environment is critical for all cells. RAS GTPase is a highly
conserved GTP-binding protein with crucial functions for cell growth and differentiation in …

Rheb, a Ras-like small GTPase conserved from human to yeast, controls Tor kinase and
plays a central role in the regulation of cell growth depending on extracellular conditions …

The target of rapamycin (Tor) plays a pivotal role in cell growth and metabolism. Yeast
contains two related proteins, Tor1 and Tor2. In fission yeast, Tor1 is dispensable for normal …

Abstract The Rheb GTPase is most similar in primary sequence to the Ras, Rap, R-Ras, and
Ral GTPases, which regulate cell growth and differentiation in many cell types. A likely …

Members of the mitogen-activated protein kinase (MAPK) subfamily responsive to
environmental stress stimuli are known as SAPKs (stress-activated protein kinases), which …

The Target Of Rapamycin (TOR) is an evolutionarily conserved protein kinase that forms 2
distinct protein complexes referred to as TOR complex 1 (TORC1) and 2 (TORC2). Recent …

RNA-binding proteins contribute to the formation of ribonucleoprotein (RNP) granules by
phase transition, but regulatory mechanisms are not fully understood. Conserved fission …

Ras1 is a small GTPase in the budding yeast Saccharomyces cerevisiae that regulates
nutrient signaling. It has been shown that Ras1 undergoes phosphorylation, but the …

TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that
promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid …

Aging is defined as a progressive decline of cognitive and physiological functions over
lifetime. Since the definition of the nine hallmarks of aging in 2013 by López-Otin, numerous …