The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …

Cutaneous somatosensory modalities play pivotal roles in generating a wide range of
sensorimotor behaviors, including protective and corrective reflexes that dynamically adapt …

Spinal dorsal horn circuits receive, process, and transmit somatosensory information. To
understand how specific components of these circuits contribute to behavior, it is critical to …

Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory
modalities including the sense of light touch. Here, we identify a population of excitatory …

Highlights•Single cell sequencing is elucidating neuronal heterogeneity within sensory
circuits.•Transcriptome, morphology, physiology, and connectome underlie functional cell …

There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …

Although pain and itch are distinct sensations, most noxious chemicals are not very specific
to one sensation over the other, and recent discoveries are revealing that Trp channels …

The encoding of touch in the spinal cord dorsal horn (DH) and its influence on tactile
representations in the brain are poorly understood. Using a range of mechanical stimuli …

Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and
relaying sensory perception and participate in the coordination of sensory-motor output …

To what extent dorsal horn interneurons contribute to the modality specific processing of
pain and itch messages is not known. Here, we report that loxp/cre-mediated CNS deletion …