The condition of oxidative stress arises when oxidant production exceeds antioxidant activity
in cells and plasma. The overabundance of oxidants is mechanistically connected to the …

We have investigated the cellular mechanisms that participate in reducing insulin sensitivity
in response to increased oxidant stress in skeletal muscle. Measurement of glucose …

Oxidative stress has been implicated as a contributor to both the onset and the progression
of diabetes and its associated complications. Some of the consequences of an oxidative …

Oxidative stress is characterized as an imbalance between the cellular production of
oxidants and the cellular antioxidant defenses and contributes to the development of …

Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-
products of metabolism. However, accumulating evidence has revealed that reactive …

In diabetes (type 1 and type 2), increased flux of free fatty acids and glucose is associated
with increased mitochondrial reactive oxygen species (ROS) production and, as a …

Oxidative stress can contribute to the multifactorial etiology of whole body and skeletal
muscle insulin resistance. No investigation has directly assessed the effect of an in vitro …

Oxidative stress is an acknowledged pathogenetic mechanism in diabetic complications.
Hyperglycemia is a widely known cause of enhanced free radical concentration, whereas …

One hallmark of the insulin-resistant state of prediabetes and overt type 2 diabetes is an
impaired ability of insulin to activate glucose transport in skeletal muscle, due to defects in …

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …