Macrophages are critical mediators of inflammation and important regulators of
developmental processes. As a key phagocytic cell type, macrophages evolved as part of …

Dynamic interactions between the hormone responsive mammary gland epithelium and
surrounding stromal macrophage populations are critical for normal development and …

Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes
in breast cancer and other solid tumors, however the identity and roles of many of the …

Breast cancer initiation, progression and metastasis rely on a complex interplay between
tumor cells and their surrounding microenvironment. Infiltrating immune cells, including …

Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence
demonstrates that macrophages, the most abundant leukocyte population in mammary …

Macrophages display remarkable plasticity, allowing these cells to adapt to changing
microenvironments and perform functions as diverse as tissue development and …

In many human cancers, the abundance of macrophages in the tumor microenvironment is
correlated with poor prognosis. Experimental evidence for the causal relationship between …

Breast cancer is the most commonly diagnosed malignant tumor in women worldwide and
contributes significantly as the primary cause of female cancer related mortality. Hence …

Alterations in extracellular matrix composition and organization are known to promote tumor
growth and metastatic progression in breast cancer through interactions with tumor cells as …

Macrophages play an important role in the immune system as a key host defense against
pathogens. Non-polarized macrophages can differentiate into pro-inflammatory classical …