Curcumin has been modified in various ways to broaden its application in medicine and
address its limitations. In this study, we present a series of curcumin-based derivatives …

Curcumin and curcuminoids have been discussed frequently due to their promising
functional groups (such as scaffolds of α, β-unsaturated β-diketone, α, β-unsaturated ketone …

A series of novel curcumin analogues were synthesized by optimization of its aromatic ring.
The antiproliferative activities of these analogues were screened against four human cancer …

Background: Inhibition of cancer cell growth and low in vivo toxicity are two important criteria
for the development of anti-cancer drugs. Curcumin is a promising candidate for developing …

In a previous study, we performed the structural modification of the curcumin skeleton by
varying substituents in phenyl rings. In continuation of that work, we now focus on the …

A series of curcumin analogues with different substituents at the 4-position of the phenyl
group were synthesized and screened for in vitro cytotoxicity against a panel of human …

Curcumin is a pharmacologically active polyphenol derived from the popular spice element-
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …

Cancers have been found to be the leading causes of death worldwide, with 8.2 million
people dying in 2012 and approximately 14 million new cases reported. These cases are …

Five novel curcumin analogues bearing different substituents at 4-position of phenyl group
were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their …

Curcumin has a surprisingly wide range of chemo-preventive and chemo-therapeutic
activities and is under investigation for the treatment of various human cancers. However …