The 190-kDa multidrug resistance protein (MRP) has recently been associated with the
transport of cysteinyl leukotrienes and several glutathione (GSH) S-conjugates. In the …

Multidrug resistance protein (MRP) is a broad specificity, primary active transporter of
organic anion conjugates that confers a multidrug resistance phenotype when transfected …

The multidrug resistance-associated protein (MRP) is the product of an ATP-binding
cassette transporter gene overexpressed in some tumor cells resistant to antineoplastic …

Multidrug resistance protein (MRP) confers a multidrug resistance phenotype similar to that
associated with overexpression of P-glycoprotein. Unlike P-glycoprotein, MRP has also …

We have previously shown that the multidrug resistance protein (MRP) mediates the ATP-
dependent membrane transport of the endogenous glutathione conjugate leukotriene C4 …

The M r 190,000 multidrug resistance protein (MRP) confers resistance to a broad spectrum
of natural product drugs. However, it has not been possible to demonstrate that MRP can …

The ATP-dependent transport of the endogenous glutathione conjugate leukotriene C4
(LTC4) was more than 25-fold higher in membrane vesicles prepared from human leukemia …

Overexpression of the multidrug resistance-associated protein (MRP1) gene encoding a
humanGS-Xpump in cultured cells resulted in increased cellular resistance to antitumor …

The proinflammatory mediators leukotriene (LT) B4 and LTC4 must be transported out of
cells before they can interact with LT receptors. Previously, we identified the multidrug …

Previous studies have identified the ATP-dependent export of glutathione conjugates as a
physiological function of the multidrug resistance protein (MRP). The involvement of MRP in …