Background. Recent experimental findings demonstrate vascular endothelial growth factor C
(VEGF-C)-mediated water-free storage of salt in the interstitium, which prevents a salt …

Hypertension is a complex trait determined by both genetic and environmental factors and is
a major public health problem due to its high prevalence and concomitant increase in the …

It has been known for decades that increased dietary intake of salt (NaCl) shortens the life
span of rats in a dose-dependent fashion. This review focuses specifically on the recently …

High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that
dietary salt loading results in dermal Na+ accumulation and lymphangiogenesis mediated …

Experimental studies suggest that salt intake plays a critical role in the progressive
glomerular filtration rate (GFR) loss of established renal disease; however, this issue has …

Salt‐sensitive hypertension is a major risk factor for renal impairment leading to chronic
kidney disease. High‐salt diet leads to hypertonic skin interstitial volume retention …

Attaining and maintaining optimal “dry weight” is one of the principal goals during
maintenance hemodialysis (MHD). Recent studies have shown a close relationship between …

Nine white and 13 black hypertensive patients with normal serum creatinine were
randomized to receive either 2 weeks of a low-salt (40 mEq Na+/d) or high-salt (200 mEq …

Objectives Several mechanisms have been proposed for salt-sensitive hypertension, with
most focusing on impaired renal sodium handling. We tested the hypothesis that …

Aim Several studies have suggested that sodium intake may affect blood pressure (BP),
proteinuria, and intrarenal transforming growth factor-β1 (TGF-β1) production in patients and …