Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …

Highlights•The Reactive Oxygen Species have an utmost importance in progression of
Depression.•Depression is associated with lowered concentration of anti-oxidants in …

Oxidative stress is viewed as an imbalance between the production of reactive oxygen
species (ROS) and their elimination by protective mechanisms, which can lead to chronic …

Affective disorders are a medical condition with a complex biological pattern of etiology,
involving genetic and epigenetic factors, along with different environmental stressors …

Major depression is a devastating disease affecting an increasing number of people from a
young age worldwide, a situation that is expected to be worsened by the COVID-19 …

Depressive disorders can affect up to 350 million people worldwide, and in developed
countries, the percentage of patients with depressive disorders may be as high as 10 …

Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

Studies of the World Health Organization suggest that in the year 2020, depressive disorder
will be the illness with the highest burden of disease. Especially unipolar depression is the …

This paper reviews recent work on the biological underpinnings of clinical depression
emphasizing the crucial role of immunoinflammatory and oxidative and nitrosative stress …

There is growing evidence that the imbalance between oxidative stress and the antioxidant
defense system may be associated with the development neuropsychiatric disorders, such …