A limitation of current gene therapy efforts aimed at central nervous system disorders
concerns distribution of vectors on direct injection into neural tissue. Here we have …

The dorsal horn of the spinal cord represents an attractive site for interventions designed to
treat chronic pain, but it has been difficult to identify small molecules that act selectively on …

Gene therapy to alleviate pain could appear surprising and perhaps not appropriate when
opioids and other active molecules are available. However, the possibility of introducing a …

Chronic pain is frequently associated with profound alterations of neuronal systems involved
in pain processing and should be considered as an actual disease state of the nervous …

Chronic pain is a major health concern affecting 80million Americans at some time in their
lives with significant associated morbidity and effects on individual quality of life. Chronic …

Chronic pain is among the most prevalent medical problems, affecting more than half of
patients with advanced cancer and many with other common diseases. Current analgesics …

We examined the pharmacologic characteristics of herpes simplex virus (HSV) vector-
mediated expression of proenkephalin in the dorsal root ganglion in a rodent model of …

Chronic pain is a highly prevalent condition that impacts adversely on individual quality of
life, imposes substantial costs on the healthcare system and a considerable burden on …

We recently described a non-viral gene therapy paradigm offering long-term resolution of
established neuropathic pain in several animal models. Here, the requirements for long-term …

The relatively low expression levels achieved from transferred genes have limited the
application of nonviral vectors for gene transfer into the spinal cord in vivo. Thus, the aim of …