Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

Distinct types of immune responses are activated by infections, which cause the
development of type I, II, or III inflammation, regulated by Th1, Th2, Th17 helper T cells and …

Thermal injury is often associated with a proinflammatory state resulting in serious
complications. After a burn, the innate immune system is activated with subsequent immune …

Sepsis refers to the deleterious and non-resolving systemic inflammatory response of the
host to microbial infection and is the leading cause of death in intensive care units. The …

Accumulating evidence indicates that aging is associated with a chronic low-level
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

We understand much about the agents, receptors, and signalling pathways that lead to
immunity to pathogens. Less is known about how the process is initiated in apparently sterile …

Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …