Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

J Rodríguez-Ubreva, A Arutyunyan, MJ Bonder… - Nature …, 2022 - nature.com
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary
immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody …

Members of the regulatory lymphocyte club in common variable immunodeficiency

S Gupta, Y Demirdag, AA Gupta - Frontiers in Immunology, 2022 - frontiersin.org
The role of CD4 T regulatory cells is well established in peripheral tolerance and the
pathogenesis of the murine model and human autoimmune diseases. CD4 T regulatory cells …

Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naive-to-memory B-cell transition

VC Rodríguez-Cortez, L del Pino-Molina… - Nature …, 2015 - nature.com
Common variable immunodeficiency (CVID), the most frequent primary immunodeficiency
characterized by loss of B-cell function, depends partly on genetic defects, and epigenetic …

Perspectives on common variable immune deficiency

JH Park, ES Resnick… - Annals of the New …, 2011 - Wiley Online Library
Common variable immunodeficiency (CVID) is considered to be a collection of genetic
immune defects with complex inheritance patterns. While the main phenotype is loss of B …

IgH sequences in common variable immune deficiency reveal altered B cell development and selection

KM Roskin, N Simchoni, Y Liu, JY Lee, K Seo… - Science translational …, 2015 - science.org
Common variable immune deficiency (CVID) is the most common symptomatic primary
immune deficiency, affecting~ 1 in 25,000 persons. These patients suffer from impaired …

Impaired CpG demethylation in common variable immunodeficiency associates with B cell phenotype and proliferation rate

L del Pino-Molina, J Rodríguez-Ubreva… - Frontiers in …, 2019 - frontiersin.org
Common Variable Immunodeficiency (CVID) is characterized by impaired antibody
production and poor terminal differentiation of the B cell compartment, yet its pathogenesis is …

Understanding the genetic and epigenetic basis of common variable immunodeficiency disorder through omics approaches

J Li, Z Wei, YR Li, SM Maggadottir, X Chang… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Background Common variable immunodeficiency disorder (CVID) is the most frequently
encountered symptomatic primary immunodeficiency, characterized by highly …

Seeking relevant biomarkers in common variable immunodeficiency

H Ho, C Cunningham-Rundles - Frontiers in Immunology, 2022 - frontiersin.org
Common variable immunodeficiency (CVID) is the most common symptomatic form of
primary immunodeficiency. More than 50% of patients in some series suffer from …

B-cell defects in common variable immunodeficiency: BCR signaling, protein clustering and hardwired gene mutations

AAJM van de Ven, EB Compeer… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Common variable immunodeficiency (CVID) is the most frequently diagnosed symptomatic
primary immunodeficiency. CVID develops as a consequence of absence or malfunction of …

Current understanding and recent developments in common variable immunodeficiency associated autoimmunity

JD Gereige, PJ Maglione - Frontiers in immunology, 2019 - frontiersin.org
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary
immunodeficiency and comprises a group of disorders with similar antibody deficiency but a …