Background IL-21 is a key player of adaptive immunity, with well-established roles in B-cell
and cytotoxic T-cell responses. IL-21 has been implicated in promotion of effector CD4+ T …

Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17
and innate lymphoid cells also in regulating airway inflammation. Herein, we have …

Background Regulatory T (Treg) cells, which prevent inflammation-induced eosinophil
infiltration, are deficient in nasal polyps (NPs) in patients with eosinophilic chronic …

Asthma is a chronic inflammatory disease of the airways that is characterized by eosinophilic
inflammation, mucus hypersecretion and airway remodeling that leads to airway obstruction …

The inflammatory cytokine interleukin (IL)-17 is involved in the pathogenesis of allergic
diseases. However, the identity and functions of IL-17–producing T cells during the …

Abstract Interleukin (IL)-12 has been shown to suppress T helper type 2 (Th2)-induced
pathogenesis that is associated with allergic asthma, largely through interferon (IFN)-γ …

Asthma is characterized by chronic airway inflammation with intense eosinophil and
lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness …

BACKGROUND: Recent evidence suggests that IL-17 contributes to airway
hyperresponsiveness (AHR); however, the mechanisms that suppress the production of this …

Rationale: The IL-23–IL-17A–producing CD4+ T-cell (Th17 cell) axis plays an important role
in the development of chronic inflammatory diseases, including autoimmune diseases …

Interleukin-21 (IL-21) is a newly described cytokine, produced by activated CD4+ T cells.
Since the discovery in 2000, IL-21 has been the object of intensive research because of its …