Bioinformatics analysis of ferroptosis in spinal cord injury

JZ Li, BY Fan, T Sun, XX Wang, JJ Li… - Neural Regeneration …, 2023 - journals.lww.com
Ferroptosis plays a key role in aggravating the progression of spinal cord injury (SCI), but
the specific mechanism remains unknown. In this study, we constructed a rat model of T10 …

Identification of ferroptotic genes in spinal cord injury at different time points: bioinformatics and experimental validation

Y Kang, Q Li, R Zhu, S Li, X Xu, X Shi, Z Yin - Molecular neurobiology, 2022 - Springer
Programmed cell death (PCD) is an important pathologic process after spinal cord injury
(SCI). As a new type of PCD, ferroptosis is involved in the secondary SCI. However, the …

[HTML][HTML] Ferroptosis related genes participate in the pathogenesis of spinal cord injury via HIF-1 signaling pathway

H Dong, C Zhang, D Shi, X Xiao, X Chen, Y Zeng… - Brain Research …, 2023 - Elsevier
Background Spinal cord injury (SCI) is a crushing disease without a effective and specific
therapeutic strategy. Therefore, it is crucial to uncover underlying mechanism in order to …

Mechanism of ferroptosis and its role in spinal cord injury

F Li, H Wang, H Chen, J Guo, X Dang, Y Ru… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is a non-necrotic form of regulated cell death (RCD) that is primarily
characterized by iron-dependent membrane lipid peroxidation and is regulated by cysteine …

[Retracted] Ferroptosis: A Novel Therapeutic Direction of Spinal Cord Injury

Q Zhao, F Liu, B Zhou, H Liu… - … Methods in Medicine, 2022 - Wiley Online Library
An injury to the spinal cord results in a crucial central nervous system event that further
causes irreversible impairment or loss of motor, autonomic, and sensory functions. A …

The ferroptosis activity is associated with neurological recovery following chronic compressive spinal cord injury

Z Yu, X Cheng, W Pan, C Yu… - Neural Regeneration …, 2023 - journals.lww.com
Chronic compressive spinal cord injury in compressive cervical myelopathy conditions can
lead to rapid neurological deterioration in the early phase, followed by partial self-recovery …

Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury

Y Zhang, C Sun, C Zhao, J Hao, Y Zhang, B Fan, BO Li… - Brain research, 2019 - Elsevier
Cell death is a key issue in spinal cord secondary injury. Ferroptosis is recently discovered
as an iron-dependent type of cell death that is distinct from other forms of cell death …

[HTML][HTML] Identification of cathepsin B as a therapeutic target for ferroptosis of macrophage after spinal cord injury

J Xu, Y Ding, C Shi, F Yuan, X Sheng, Y Liu… - Aging and …, 2024 - ncbi.nlm.nih.gov
Hemorrhage and immune cell infiltration are the main pathological features of spinal cord
injury (SCI). Excessive iron deposition is caused by leaking hemosiderin which may over …

Hmox1 is identified as a ferroptosis hub gene and Associated with the M1 type microglia/macrophage polarization in spinal cord injury: bioinformatics and …

Y Xuan, K Peng, R Zhu, Y Kang, Z Yin - Molecular Neurobiology, 2023 - Springer
Ferroptosis and immune cell infiltration are important pathological events in spinal cord
injury (SCI), but links between ferroptosis and immune microenvironment after SCI were rare …

The latest view on the mechanism of ferroptosis and its research progress in spinal cord injury

Y Chen, S Liu, J Li, Z Li, J Quan, X Liu… - Oxidative medicine …, 2020 - Wiley Online Library
Ferroptosis is a recently identified nonapoptotic form of cell death whose major markers are
iron dependence and accumulation of lipid reactive oxygen species, accompanied by …