In 1972 Guido Biozzi selectively bred mice to study the immunopathological mechanisms
underlying polygenic diseases. One line, the Biozzi antibody high (AB/H) mouse (now …

Current therapies for multiple sclerosis (MS) reduce the frequency of relapses by modulating
adaptive immune responses but fail to limit the irreversible neurodegeneration driving …

Biozzi ABH mice develop a reproducible, relapsing–remitting form of experimental
autoimmune encephalomyelitis (EAE) that becomes secondary progressive with disease …

We studied the cellular basis of self tolerance of B cells specific for brain autoantigens using
transgenic mice engineered to produce high titers of autoantibodies against the myelin …

Experimental allergic encephalomyelitis (EAE) was induced in Biozzi AB/H (antibody high)
mice by sensitization with spinal cord homogenate in adjuvant. Biozzi AB/H mice were …

Multiple sclerosis is an immune-mediated demyelinating disease, with axonal loss
underlying long-term progressive disability. In this study, we have analyzed axonal and …

Previous studies have shown that immunization of the Lewis rat with myelin basic protein
(MBP), an encephalitogenic antigen derived from the myelin sheath of the CNS, induced …

The cause of multiple sclerosis (MS) is unknown, but the pathology is consistent with an
immunological etiology. Studies conducted with the animal model of MS, experimental …

Brain-reactive autoantibodies (BRAA) are thought to play an important role in central
nervous system (CNS) manifestations of systemic lupus erythematosus (SLE). Previous …

It is widely accepted that the precise subcellular location of a protein critically affects its
functional role. Let us demonstrate this point with two elegant examples. Neurotransmitter …