The distribution of fitness effects (DFE) defines how new mutations spread through an
evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has …

Novel sequencing technologies are making it increasingly possible to measure the mutation
rates of somatic cell lineages. Accurate germline mutation rate measurement technologies …

Mutation rate is a crucial evolutionary parameter that has typically been treated as a
constant in population genetic analyses. However, the propensity to mutate is likely to vary …

Somatic tissue evolves over a vertebrate's lifetime due to the accumulation of mutations in
stem cell populations. Mutations may alter cellular fitness and contribute to tumorigenesis or …

The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics
that has implications ranging from the genetic basis of complex disease to the stability of the …

Recently available cancer sequencing data have revealed a complex view of the cancer
genome containing a multitude of mutations, including drivers responsible for cancer …

The distribution of fitness effects of new mutations (DFE) is important for addressing several
questions in genetics, including the nature of quantitative variation and the evolutionary fate …

Spontaneous mutations are stochastic events. The mutation rate, defined as mutations per
genome per replication, is generally very low, and it is widely accepted that spontaneous …

Background. In a companion paper, careful numerical simulation was used to demonstrate
that there is a quantifiable selection threshold, below which low-impact deleterious …

Highly sensitive DNA sequencing techniques have allowed the discovery of large numbers
of somatic mutations in normal tissues. Some mutations confer a competitive advantage over …