[HTML][HTML] Development of a sustained release implant of benzathine penicillin G for secondary prophylaxis of rheumatic heart disease
RK Barr, BW Barber, JR Tait, CB Landersdorfer… - European Journal of …, 2023 - Elsevier
Background Regular intramuscular (im) benzathine penicillin G (BPG) injections have been
the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s …
the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s …
Subcutaneous infusion of high-dose benzathine penicillin G is safe, tolerable, and suitable for less-frequent dosing for rheumatic heart disease secondary prophylaxis …
Since 1955, the recommended strategy for rheumatic heart disease (RHD) secondary
prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)] injections …
prophylaxis has been benzathine penicillin G [BPG; 1.2 MU (900 mg)] injections …
Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD)
OD Montagnat, GR Webster, JB Bulitta… - Drug Delivery and …, 2018 - Springer
The current prophylactic treatment to prevent rheumatic heart disease requires four-weekly
intramuscular injection of a suspension of the poorly soluble benzathine salt form of …
intramuscular injection of a suspension of the poorly soluble benzathine salt form of …
Qualitative assessment of healthy volunteer experience receiving subcutaneous infusions of high-dose benzathine penicillin G (SCIP) provides insights into design of …
Introduction Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression,
in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has …
in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has …
Subcutaneous infusions of high-dose Benzathine penicillin G (SCIP) is safe, tolerable and potentially suitable for less frequent dosing for rheumatic heart disease …
Methods The safety, tolerability, and pharmacokinetics of SubCutaneous Infusions of high-
dose BPG (SCIP) was assessed in 24 healthy adult volunteers assigned to receive either …
dose BPG (SCIP) was assessed in 24 healthy adult volunteers assigned to receive either …
Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared …
JH Kado, S Salman, R Henderson… - Journal of …, 2020 - academic.oup.com
Background Benzathine penicillin G has been used as monthly deep intramuscular (IM)
injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic …
injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic …
[HTML][HTML] Local anaesthetic to reduce injection pain in patients who are prescribed intramuscular benzathine penicillin G: a systematic review and meta-analysis
F Pelone, B Kwok, S Ahmed, Y Kilic, SA Ali… - …, 2024 - thelancet.com
Background Three to 4-weekly intramuscular injections of benzathine penicillin G (BPG) for
a prolonged period (eg, 10 years, until age 40 years, or lifelong) are recommended for …
a prolonged period (eg, 10 years, until age 40 years, or lifelong) are recommended for …
Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever
Rheumatic fever is caused by an abnormal immune reaction to group A streptococcal
infection. Secondary prophylaxis with antibiotics is recommended for people after their initial …
infection. Secondary prophylaxis with antibiotics is recommended for people after their initial …
The risk of intramuscular haematoma is low following injection of benzathine penicillin G in patients receiving concomitant anticoagulant therapy
E Fox, J Misko, M Rawlins, L Manning - Journal of Thrombosis and …, 2020 - Springer
The use of intramuscular injections is widely recommended to be avoided in patients who
are prescribed anticoagulant agents, both oral and parenteral due to concerns of …
are prescribed anticoagulant agents, both oral and parenteral due to concerns of …
[HTML][HTML] Intramuscular versus Enteral Penicillin Prophylaxis to Prevent Progression of Rheumatic Heart Disease: Study protocol for a non-inferiority randomized trial …
J Rwebembera, E Ndagire, N Carvalho, AR Webel… - American Heart …, 2024 - Elsevier
ABSTRACT Background Rheumatic Heart Disease (RHD) persists as a major
cardiovascular driver of mortality and morbidity among young people in low-and middle …
cardiovascular driver of mortality and morbidity among young people in low-and middle …
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