Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This
process is also of considerable interest for better understanding anemias and identifying …

Mammalian erythropoiesis yields a highly specialized cell type, the mature erythrocyte,
evolved to meet the organismal needs of increased oxygen-carrying capacity. To better …

Transcriptional networks orchestrate fundamental biological processes, including
hematopoiesis, in which hematopoietic stem cells progressively differentiate into specific …

Interplays among lineage-specific nuclear proteins, chromatin modifying enzymes, and the
basal transcription machinery govern cellular differentiation, but their dynamics of action and …

To enable effective oxygen transport,∼ 200 billion red blood cells (RBCs) need to be
produced every day in the bone marrow through the fine-tuned process of erythropoiesis …

Background Single-cell technologies are transforming biomedical research, including the
recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits …

KLF1 (formerly known as EKLF) regulates the development of erythroid cells from bi-potent
progenitor cells via the transcriptional activation of a diverse set of genes. Mice lacking Klf1 …

Erythropoiesis is dependent on the activity of transcription factors, including the erythroid-
specific erythroid Kruppel-like factor (EKLF). ChIP followed by massively parallel …

We recently developed fluorescence-activated cell sorting (FACS)-based methods to purify
morphologically and functionally discrete populations of cells, each representing specific …

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent
progenitors. To determine the local cis-regulatory contexts and transcription factor networks …