Background Prostate cancer is highly heritable, with> 250 common variants associated in
genome-wide association studies. It commonly presents with non-specific lower urinary tract …

Prostate cancer (PrCa) is the most commonly diagnosed cancer in the male UK population,
with over 40,000 new cases per year. PrCa has a complex, polygenic predisposition, due to …

Objectives To develop and validate a genetic tool to predict age of onset of aggressive
prostate cancer (PCa) and to guide decisions of who to screen and at what age. Design …

What's known on the subject? and What does the study add? Family history (FH) is a major
risk factor for the development of prostate cancer. The search for genetic variants has led to …

Abstract Context Prostate cancer (PCa) is a leading cause of death and partially heritable.
Genetic risk prediction might be useful for strategies to reduce PCa mortality through early …

Hereditary factors have a strong influence on prostate cancer (PC) risk and poorer
outcomes, thus stratification by genetic factors addresses a critical need for targeted PC …

BACKGROUND Polygenic risk scores comprising established susceptibility variants have
shown to be informative classifiers for several complex diseases including prostate cancer …

BACKGROUND While family history (FH) has been widely used to provide risk information, it
captures only a small proportion of subjects with higher genetic susceptibility. Our objective …

Background Genome‐wide association studies have identified over 100 single‐nucleotide
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …

Background: Several prostate cancer genome-wide association studies (GWAS) have
identified risk-associated genetic variants primarily in populations of European descent …