Islet transplant is a curative treatment for insulin-dependent diabetes. However, challenges,
including poor tissue survival and a lack of efficient engraftment, must be overcome. An …

A closed-loop system that provides both the sensing of glucose and the appropriate dosage
of insulin could dramatically improve treatment options for insulin-dependent diabetics. The …

Cell-based therapies are emerging for type I diabetes mellitus (T1D), an autoimmune
disease characterized by the destruction of insulin-producing pancreatic β-cells, as a means …

Abstract Purpose of Review Type 1 diabetes (T1D) is an autoimmune disease characterized
by the loss of insulin-producing cells in pancreatic islets. Despite islet transplantation is …

The worldwide prevalence of type 1 diabetes motivates the development of different
treatment options for the disease. Current clinical treatments typically require patient …

The effective suppression of adaptive immune responses is essential for the success of
allogeneic cell therapies. In islet transplantation for Type 1 Diabetes, pre-existing …

The microvasculature in the pancreatic islet is highly specialized for glucose sensing and
insulin secretion. Although pancreatic islet transplantation is a potentially life-changing …

Abstract Type 1 Diabetes (T1D) involves the autoimmune destruction of insulin-producing β-
cells in the pancreas. Exogenous insulin injections are the current therapy but are user …

Cellular therapies for type-1 diabetes can leverage cell encapsulation to dispense with
immunosuppression. However, encapsulated islet cells do not survive long, particularly …

Type 1 diabetes mellitus (T1DM) is a chronic metabolic disease caused by the destruction of
pancreatic β‐cells in response to autoimmune reactions. Shapiro et al. conducted novel islet …